Renal toxicity has been described in the literature but would not be expected from ambient air exposure.
Groups of 50 rats and 50 mice of each sex received corn oil by gavage on the same schedule and served as vehicle controls. Trichloroethylene without epichlorohydrin was carcinogenic for B6C3F1 mice, causing increased incidences of hepatocellular carcinomas in males and females and of hepatocellular adenomas in females.
Several studies have reported reproductive or developmental abnormalities thought to be associated with exposure to TCE in drinking water. Reproductive and Developmental Effects Adverse effects were noted in residents of several communities where TCE was found to be present in drinking water Bove, Shim et al.
A cohort study of male workers having been exposed to unusually high levels of TCE in Germany between and supported a nephrocarcinogenic effect of TCE in humans. When TCE was administered as an anesthetic agent, serious ventricular arrhythmias and cardiac arrests were rare and were nearly always associated with hypoxia Norris and Stuart ; Agency for Toxic Substances and Disease Registry Significant cardiac effects would not be expected from TCE exposure at background environmental levels or those currently allowed in the workplace.
Chronic occupational TCE exposure has been associated with neurological abnormalities. Trichloroethylene is no longer used with food, drugs, or cosmetics.
Thus, risks from TCE exposure to human lung damage are minimal Green Trichloroethylene TCE is an industrial solvent used for vapor degreasing and cold cleaning of fabricated metal parts.
In female rats, one tubular cell adenocarcinoma was found in the high dose group.
The dosage levels selected for the 2-year study were based on the results of the week studies. A meta-analysis of these cohort studies found that occupational exposure to TCE was associated with excess incidences of liver cancer, kidney cancer, non-Hodgkin's lymphoma, prostate cancer, and multiple myeloma, with the strongest evidence for the first three cancers Wartenberg, Reyner et al.